Immunology of placentation in eutherian mammals

被引：643

作者：

Moffett, Ashley ^{[1
]}

Loke, Charlie ^{[1
]}

机构：

[1] Kings Coll London, Cambridge CB2 1ST, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2006年 / 6卷 / 08期

关键词：

D O I：

10.1038/nri1897

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The traditional way to study the immunology of pregnancy follows the classical transplantation model, which views the fetus as an allograft. A more recent approach, which is the subject of this Review, focuses on the unique, local uterine immune response to the implanting placenta. This approach requires knowledge of placental structure and its variations in different species, as this greatly affects the type of immune response that is generated by the mother. At the implantation site, cells from the mother and the fetus intermingle during pregnancy. Unravelling what happens here is crucial to our understanding of why some human pregnancies are successful whereas others are not.

引用

页码：584 / 594

页数：11

共 95 条

[1] Natural selection drives recurrent formation of activating killer cell immunoglobulin-like receptor and Ly49 from inhibitory homologues [J].