Alleviation of Brain Edema and Restoration of Functional Independence by Bevacizumab in Brain-Metastatic Breast Cancer: A Case Report

被引：21

作者：

Berghoff, Anna S. ^{[1
,7
]}

Sax, Cornelia ^{[1
,7
]}

Klein, Martin ^{[2
]}

Furtner, Julia ^{[3
,7
]}

Dieckmann, Karin ^{[4
,7
]}

Gatterbauer, Brigitte ^{[5
,7
]}

Widhalm, Georg ^{[5
,7
]}

Rudas, Margaretha ^{[6
]}

Zielinski, Christoph C. ^{[1
,7
]}

Bartsch, Rupert ^{[1
,7
]}

Preusser, Matthias ^{[1
,7
]}

机构：

[1] Med Univ Vienna, Dept Med 1, A-1090 Vienna, Austria

[2] Vrije Univ Amsterdam Med Ctr, Dept Med Psychol, Amsterdam, Netherlands

[3] Med Univ Vienna, Dept Neuroradiol, A-1090 Vienna, Austria

[4] Med Univ Vienna, Dept Radiotherapy, A-1090 Vienna, Austria

[5] Med Univ Vienna, Dept Neurosurg, A-1090 Vienna, Austria

[6] Med Univ Vienna, Dept Pathol, A-1090 Vienna, Austria

[7] Med Univ Vienna, Ctr Comprehens Canc, CNS Tumors Unit CCC CNS, A-1090 Vienna, Austria

来源：

BREAST CARE | 2014年 / 9卷 / 02期

关键词：

Breast cancer; Brain metastases; Neurocognitive functioning; Bevacizumab; Symptom control; Brain edema; NORMATIVE DATA; TEST SCORE; SURVIVAL; RELIABILITY; PROGRESSION; RADIATION; OUTCOMES; TUMORS; NORMS;

D O I：

10.1159/000360930

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Background: Brain metastases (BM) are an increasing challenge in modern oncology, as treatment options especially after exhaustion of local treatment approaches are very limited. Patient and Methods: A long-term surviving patient with brain-only metastatic breast cancer, who presented at our department with massive corticosteroid-refractory brain edema with serious neuro-logical symptoms after exhaustion of all local therapy options, was started on bevacizumab. Results: Initiation of bevacizumab monotherapy led to rapid decrease of contrast-enhancing lesions and alleviation of brain edema, and allowed tapering and termination of corticosteroid administration. Neurological and neurocognitive function was restored and marked improvement in quality of life was observed. Conclusion: Our case highlights that bevacizumab may represent a feasible and effective salvage treatment option in selected patients with BM.

引用

页码：134 / 136

页数：3

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