Thermal effects on electrospray ionization ion mobility spectrometry

被引：48

作者：

Chen, YH

Hill, HH

Wittmer, DP

机构：

[1] WASHINGTON STATE UNIV,DEPT CHEM,PULLMAN,WA 99164

[2] MILLIPORE CORP,DIV WATERS CHROMATOG,MILFORD,MA 01757

来源：

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES | 1996年 / 154卷 / 1-2期

关键词：

electrospray ionization; ion mobility detection; ion mobility spectrometry; liquid chromatography detector; polymer analysis;

D O I：

10.1016/0168-1176(96)04370-4

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

A cooled electrospray ionization source was used to introduce liquid sample into an ion mobility spectrometer. This uniquely designed electrospray ionization source eliminated problems encountered in the past when electrospray sources were interfaced to ion mobility spectrometers. Advantages of this electrospray ionization ion mobility instrument included high temperature operation for rapid desolvation of sprayed droplets, prevention of solute precipitation in the spray needle, efficient transmission of ion spray into the spectrometer and complete elimination of corona ionization. Parametric investigations included drift tube temperature, spray needle temperature, solvent how rate and electrospray voltage. Ion mobility spectra of cytochrome c and poly(ethylene glycol) demonstrated good sensitivity and resolution for high molecular weight compounds sprayed from liquid samples.

引用

页码：1 / 13

页数：13

共 19 条

[1] DESIGN AND PERFORMANCE OF A NOVEL ELECTROSPRAY INTERFACE
ALLEN, MH
VESTAL, ML
[J]. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 1992, 3 (01) : 18 - 26
[2] Carrier mobility spectra of spray electrified liquids
Chapman, S
[J]. PHYSICAL REVIEW, 1937, 52 (03): : 0184 - 0190
[3] CHEN YH, 1994, J MICROCOLUMN SEP, V6, P512
[4] CHEN YH, 1995, 27 ACS CENTR REG M A
[5] EATHERTON EL, 1987, THESIS WASHINGTON ST
[6] GIENIEC J, 1972, 20TH ANN C MASS SPEC, P267
[7] THE CORONA DISCHARGE, ITS PROPERTIES AND SPECIFIC USES
GOLDMAN, M
GOLDMAN, A
SIGMOND, RS
[J]. PURE AND APPLIED CHEMISTRY, 1985, 57 (09) : 1353 - 1362
[8] PRELIMINARY INVESTIGATION OF ION MOBILITY SPECTROMETRY AFTER CAPILLARY ELECTROPHORETIC INTRODUCTION
HALLEN, RW
SHUMATE, CB
SIEMS, WF
TSUDA, T
HILL, HH
[J]. JOURNAL OF CHROMATOGRAPHY, 1989, 480 : 233 - 245
[9] HILL HH, 1986, 1986 ANN REPORT NIH
[10] ELECTROSPRAY MASS-SPECTROMETRY OF METHANOL AND WATER SOLUTIONS SUPPRESSION OF ELECTRIC-DISCHARGE WITH SF6 GAS
IKONOMOU, MG
BLADES, AT
KEBARLE, P
[J]. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 1991, 2 (06) : 497 - 505

← 1 2 →