Interfering antiviral immunity: application, subversion, hope?

被引：18

作者：

Manjunath, N.

Kumar, Priti

Lee, Sang Kyung

Shankar, Premlata ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, CBR Inst Biomed Res, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

[3] Hanyang Univ, Dept Bioengn, Seoul 133791, South Korea

来源：

TRENDS IN IMMUNOLOGY | 2006年 / 27卷 / 07期

关键词：

D O I：

10.1016/j.it.2006.05.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

RNA interference (RNAi), initially recognized as a natural antiviral mechanism in plants, has rapidly emerged as an invaluable tool to suppress gene expression in a sequence-specific manner in all organisms, including mammals. Its potential to inhibit the replication of a variety of viruses has been demonstrated in vitro and in vivo in mouse and monkey models. These results have generated profound interest in the use of this technology as a potential treatment strategy for viral infections for which vaccines and drugs are unavailable or inadequate. In this review, we discuss the progress made within the past 2-3 years towards harnessing the potential of RNAi for clinical application in viral infections and the hurdles that have yet to be overcome.

引用

页码：328 / 335

页数：8

共 73 条

[1] Use of RNA interference to prevent lethal murine West Nile virus infection [J].