CARD15/NOD2 mutations in Crohn's disease

被引：59

作者：

Hugot, Jean-Pierre ^{[1
]}

机构：

[1] Hop Robert Debre, INSERM Avenir, U458, Dept Paediat Gastroenterol, F-75019 Paris, France

来源：

INFLAMMATORY BOWEL DISEASE: GENETICS, BARRIER FUNCTION, IMMUNOLOGIC MECHANISMS, AND MICROBIAL PATHWAYS | 2006年 / 1072卷

关键词：

inflammatory bowel disease; Crohn's disease; NOD2; CARD15; complex genetic disorders; innate immunity;

D O I：

10.1196/annals.1326.011

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Inflammatory bowel diseases (IBDs) are complex genetic disorders characterized by a complex interplay between genetic and environmental risk factors. At least ten genes or anonymous loci have been proposed to play a role in IBD. Among them, the best studied is CARD15/NOD2, a gene coding for a protein involved in bacterial recognition by cells involved in innate immunity. Despite a large amount of work, a consensus model explaining the effect of Card 15/NoD2 mutations did not emerge, and the disease mechanisms are still subject to debate.

引用

页码：9 / 18

页数：10

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