Control of cell survival by IGF signaling pathways

被引：235

作者：

Vincent, AM ^{[1
]}

Feldman, EL ^{[1
]}

机构：

[1] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA

来源：

GROWTH HORMONE & IGF RESEARCH | 2002年 / 12卷 / 04期

关键词：

Akt/protein kinase B; apoptosis; insulin-like growth factor-1; phosphorylation;

D O I：

10.1016/S1096-6374(02)00017-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The insulin-like growth factor system efficiently signals to cells to grow, differentiate, and survive. One central player in the prevention of cell death is the IGF-I receptor. Transduction of signals through this receptor leads to multiple series of intracellular phosphorylation events and the activation of several signaling pathways. Mechanisms of IGF system signaling that prevent cell death continue to be identified, suggesting that cells have alternative ways to avert death signals in addition to primary protective pathways. This review describes current knowledge of the mechanisms utilized by the IGF system to promote cell survival. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：193 / 197

页数：5

共 45 条

[1] Role of AKT1 in 17β-estradiol- and insulin-like growth factor I (IGE-I)-dependent proliferation and prevention of apoptosis in MCF-7 breast carcinoma cells [J].