Donepezil - A review of its use in Alzheimer's disease

Data Selection Sources: Medical literature published in any language since 1966 on donepezil, identified using AdisBase (a proprietary database of Adis International, Auckland, New Zealand) and Medline. Additional references were identified from the reference lists of published articles. Bibliographical information, including contributory unpublished data, was also requested from the company developing the drug. Search strategy: AdisBase search terms were 'donepezil' or 'E-2020': Medline search terms were 'donepezil' or 'E-2020': Searches were last updated 12 Jan 2000. Selection: Studies in patients with Alzheimer's disease who received donepezil. inclusion of studies was based mainly on the methods section of the trials. When available, large. well controlled trials with appropriate statistical methodology were preferred. Relevant pharmacodynamic and pharmacokinetic data are also included.