Evolution of Rh blood group genes have experienced gene conversions and positive selection

被引:33
作者
Kitano, T [1 ]
Saitou, N [1 ]
机构
[1] Natl Inst Genet, Lab Evolutionary Genet, Mishima, Shizuoka 4118540, Japan
关键词
Rh blood group; gene conversion; positive selection;
D O I
10.1007/PL00006583
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
There are two tightly linked loci (D and CE) for the human Rh blood group. Their gene products are membrane proteins having 12 transmembrane domains and form a complex with Rh50 glycoprotein on erythrocytes. We constructed phylogenetic networks of human and nonhuman primate Ph genes, and the network patterns suggested the occurrences of gene conversions. We therefore used a modified site-by-site reconstruction method by using two assumed gene trees and detected 9 or 11 converted regions. After eliminating the effect of gene conversions, we estimated numbers of nonsynonymous and synonymous substitutions for each branch of both trees. Whichever gene tree we selected the branch connecting hominoids and Old World monkeys showed significantly higher nonsynonymous than synonymous substitutions, an indication of positive selection. Many other branches also showed higher nonsynonymous than synonymous substitutions; this suggests that the Ph genes have experienced some kind of positive selection.
引用
收藏
页码:615 / 626
页数:12
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