Highly ordered and tunable polyHIPEs by using microfluidics

被引：76

作者：

Costantini, Marco ^{[1
]}

Colosi, Cristina ^{[1
]}

Guzowski, Jan ^{[2
]}

Barbetta, Andrea ^{[1
]}

Jaroszewicz, Jakub ^{[3
]}

Swieszkowski, Wojciech ^{[3
]}

Dentini, Mariella ^{[1
]}

Garstecki, Piotr ^{[2
]}

机构：

[1] Sapienza Univ Rome, Dept Chem, I-00185 Rome, Italy

[2] Polish Acad Sci, Inst Chem Phys, PL-01224 Warsaw, Poland

[3] Warsaw Univ Technol, Fac Mat Sci & Engn, PL-02507 Warsaw, Poland

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2014年 / 2卷 / 16期

基金：

欧洲研究理事会;

关键词：

EMULSION-TEMPLATED SCAFFOLDS; GLYCIDYL METHACRYLATE; INJECTABLE POLYHIPES; OSTEOBLAST GROWTH; POROUS POLYMERS; GELATIN; POLYMERIZATION; ARCHITECTURE; GENERATION; MORPHOLOGY;

D O I：

10.1039/c3tb21227k

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

082905 [生物质能源与材料]; 100103 [病原生物学];

摘要：

We demonstrate how to generate highly ordered porous matrices from dextran-methacrylate (DEX-MA) using microfluidics. We use a flow focusing device to inject an aqueous solution of DEX-MA and surfactant to break the flow of an organic solvent (cyclohexane) into monodisperse droplets at a high volume fraction (above 74% v/v) to form an ordered high internal phase emulsion (HIPE). We collect the crystalline HIPE structure and freeze it by gelling. The resulting polyHIPEs are characterized by an interconnected and ordered morphology. The size of pores and interconnects ranges between hundreds and tens of micrometers, respectively. The technique that we describe allows for precise tuning of all the structural parameters of the matrices, including their porosity, the size of the pores and the lumen of interconnects between the pores. The resulting ordered and precisely tailored HIPE gels represent a new class of scaffolds for applications in tissue engineering.

引用

页码：2290 / 2300

页数：11

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