New cytotoxic Briaran diterpenes from the formosan gorgonian Briareum sp

被引：61

作者：

Sheu, JH

Sung, PJ

Huang, LH

Lee, SF

Wu, TH

Chang, BY

Duh, CY

Fang, LS

Soong, K

Lee, TJ

机构：

[1] NATL SUN YAT SEN UNIV,INST MARINE BIOL,KAOHSIUNG 804,TAIWAN

[2] NATL TSING HUA UNIV,DEPT PHYS,HSINCHU 300,TAIWAN

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 10期

关键词：

D O I：

10.1021/np960218s

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new briaran diterpenes, 2 beta-acetoxy-2-(debutyryloxy) stecholide E (3), 9 -deacetylstylatulide lactone (4), and 4 beta-acetoxy-9-deacetylstylatulide lactone (5), and two known diterpenes, brianthein W (1) and 9-deacetylbriareolide H (2), have been isolated from a Briareum sp. of gorgonian. The structures and relative stereochemistry of these compounds were determined by spectroscopic and chemical methods. Diterpenes 2-4 and the corresponding 9-acetyl derivatives 6, 7, and 12 exhibited cytotoxicity toward various cancer cell lines.

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页码：935 / 938

页数：4

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