Ezetimibe/simvastatin single tablet versus rosuvastatin in patients with hypercholesterolemia

被引：8

作者：

Daskalopoulou, Stella S.

Mikhailidis, Dimitri P.

机构：

[1] Univ London, Sch Med, Royal Free & Univ Coll, London NW3 2QG, England

[2] McGill Univ, Royal Victoria Hosp, Dept Med, Div Clin Epidemiol, Montreal, PQ H3A 1A1, Canada

来源：

CURRENT MEDICAL RESEARCH AND OPINION | 2006年 / 22卷 / 10期

关键词：

combination therapy; ezetimibe; guidelines; liver function tests; low density lipoprotein cholesterol; rosuvastatin; simvastatin;

D O I：

10.1185/030079906X148364

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent guidelines recommend strict goals for low density lipoprotein cholesterol ( LDL-C) ( 70 - 100 mg/dL; 1.8 - 2.6 mmol/L). These goals were set following the publication of several trials. In the current issue of the journal, a study compares different doses of the combination tablet ( ezetimibe/simvastatin) with statin monotherapy ( rosuvastatin). In keeping with previous literature, the combination therapy was more effective in achieving LDL-C goals. This editorial comments on the potential disadvantages of using monotherapy with high-dose statins and considers the issue of statin-induced proteinuria. Combination therapy may need to be increasingly used to achieve the LDL-C targets set by recent guidelines.

引用

收藏

页码：2037 / 2039

页数：3

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