SHP-2 is involved in neurotrophin signaling

被引：25

作者：

Okada, N ^{[1
]}

Wada, K ^{[1
]}

Goldsmith, BA ^{[1
]}

Koizumi, S ^{[1
]}

机构：

[1] CIBA GEIGY LTD,INT RES LABS,BIOORGAN RES DEPT,TAKARAZUKA,HYOGO 665,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 229卷 / 02期

关键词：

D O I：

10.1006/bbrc.1996.1851

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To investigate the involvement of SHP-2 in the signal transduction pathway stimulated by neurotrophins, the association of SHP-2 with components of the pathway was examined. Following NGF stimulation of PC12 cells, SHP-2 was found to be associated with the p85 subunit of PI3-kinase and the She proteins. In retinoic acid-differentiated SH-SY5Y cells and primary cultures of rat cortical neurons, BDNF treatment similarly caused the association of SHP-2 with p85. In addition, a tyrosine-phosphorylated protein, which is probably TrkB, was coimmunoprecipitated with SHP-2 in both cultures. These results show that SHP-2 becomes associated with signaling proteins after treatment with neurotrophins and suggest that SHP-2 plays a fundamental role in neurotrophin signaling. (C) 1996 Academic Press, Inc.

引用

页码：607 / 611

页数：5

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