Mucosal vaccination and immune responses in the elderly

被引：31

作者：

Fujihashi, K ^{[1
]}

Koga, T ^{[1
]}

McGhee, JR ^{[1
]}

机构：

[1] Univ Alabama, Med Ctr, Immunobiol Vaccine Ctr, Birmingham, AL 35294 USA

来源：

VACCINE | 2000年 / 18卷 / 16期

关键词：

mucosa; vaccination; elderly;

D O I：

10.1016/S0264-410X(99)00505-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To develop a mucosal vaccine strategy for the elderly, we have compared mucosal and systemic immune responses between aged (12-14 months) and young adult (8-12 weeks) mice. Both aged and young mice were immunized weekly with three oral doses of 1 mg of ovalbumin (OVA) and 10 mu g of cholera toxin as adjuvant. Although elevated levels of OVA-specific systemic IgG and mucosal IgA Ab responses were seen in young mice, aged mice showed impaired antigen-specific mucosal and systemic immune responses. These results suggest that mucosal immunity is down regulated in aged mice. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1675 / 1680

页数：6

共 45 条

[1] INTERLEUKINS AND IGA SYNTHESIS - HUMAN AND MURINE INTERLEUKIN-6 INDUCE HIGH-RATE IGA SECRETION IN IGA-COMMITTED B-CELLS [J].

BEAGLEY, KW ;

ELDRIDGE, JH ;

LEE, F ;

KIYONO, H ;

EVERSON, MP ;

KOOPMAN, WJ ;

HIRANO, T ;

KISHIMOTO, T ;

MCGHEE, JR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (06) :2133-2148

[2]

BEAGLEY KW, 1988, J IMMUNOL, V141, P2035

[3]

Brandtzaeg P, 1995, IMMUNOLOGIST, V3, P89

[4]

Bromander AK, 1996, J IMMUNOL, V156, P4290

[5] ADJUVANT ACTIVITY OF ESCHERICHIA-COLI HEAT-LABILE ENTERO-TOXIN AND EFFECT ON THE INDUCTION OF ORAL TOLERANCE IN MICE TO UNRELATED PROTEIN ANTIGENS [J].

CLEMENTS, JD ;

HARTZOG, NM ;

LYON, FL .

VACCINE, 1988, 6 (03) :269-277

[6]

COFFMAN RL, 1987, J IMMUNOL, V139, P3685

[7] DISSOCIATION OF ESCHERICHIA-COLI HEAT-LABILE ENTEROTOXIN ADJUVANTICITY FROM ADP-RIBOSYLTRANSFERASE ACTIVITY [J].

DICKINSON, BL ;

CLEMENTS, JD .

INFECTION AND IMMUNITY, 1995, 63 (05) :1617-1623

[8] Induction of antigen-specific antibodies in vaginal secretions by using a nontoxic mutant of Hsai-Labile enterotoxin as a mucosal adjuvant [J].

DiTommaso, A ;

Saletti, G ;

Pizza, M ;

Rappuoli, R ;

Dougan, G ;

Abrignani, S ;

Douce, G ;

DeMagistris, M .

INFECTION AND IMMUNITY, 1996, 64 (03) :974-979

[9] MUTANTS OF ESCHERICHIA-COLI HEAT-LABILE TOXIN LACKING ADP-RIBOSYLTRANSFERASE ACTIVITY ACT AS NONTOXIC, MUCOSAL ADJUVANTS [J].

DOUCE, G ;

TURCOTTE, C ;

CROPLEY, I ;

ROBERTS, M ;

PIZZA, M ;

DOMENGHINI, M ;

RAPPUOLI, R ;

DOUGAN, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (05) :1644-1648

[10]

ELSON CO, 1984, J IMMUNOL, V133, P2892

← 1 2 3 4 5 →