Effects of interferon-γ on neuronal infections

被引：24

作者：

Rottenberg, M

Kristensson, K

机构：

[1] Karolinska Inst, Dept Neurosci, SE-17177 Stockholm, Sweden

[2] Karolinska Inst, Ctr Microbiol & Tumor Biol, Stockholm, Sweden

来源：

VIRAL IMMUNOLOGY | 2002年 / 15卷 / 02期

关键词：

D O I：

10.1089/08828240260066206

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IFN-gamma is released in the brain, not only during acute infectious diseases or immunological reactions, but also for extended periods of time after clearance of infectious virus and during viral latency. In this review, we focus on the role of IFN-gamma in the interaction between a neuron and a pathogen, that is, the role in implementation of microbial destruction, stasis or persistence, its potential neuroprotective or toxic effects, and how this cytokine may affect neuronal function and the behavior of an individual.

引用

页码：247 / 260

页数：14

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[1] Increased expression of Rab5a correlates directly with accelerated maturation of Listeria monocytogenes phagosomes [J].