FT-IR and FT-Raman spectra of cimetidine and its metallocomplexes

被引:20
作者
Baranska, M
Proniewicz, LM
机构
[1] Jagiellonian Univ, Dept Chem, Div Phys Chem, PL-30060 Krakow, Poland
[2] Jagiellonian Univ, Reg Lab Physicochem Anal & Struct Res, Laser Raman Lab, PL-30060 Krakow, Poland
关键词
cimetidine; polymorphs; FT-IR; FT-Raman; metallocomplexes;
D O I
10.1016/S0022-2860(99)00154-4
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
We present vibrational spectra of three stable, well-reproducible, polymorphic forms of cimetidine (cim), a drug which is a powerful histamine Hz-receptor antagonist used in the treatment of peptic ulcer and the Zollinger-Ellison syndrome. Assignments of Raman and IR bands are made using semiempirical methods: MNDO, AM1 and PM3. We also describe the synthesis of Me(cim)(2)(ClO4)(2), where Me = Cu(ZI), Cd(II), Co(II) and Ni(LI), and present their vibrational data. We show that the obtained complexes are isostructural, however a metal ion that occupies a center of octahedral unit introduces some distortions that can be seen in the spectra, We also make tentative assignment of metal-ligand stretching modes observed in low frequency range. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:153 / 162
页数:10
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