A concise semi-synthetic approach to betulinic acid from betulin

被引：151

作者：

Kim, DSHL

Chen, ZD

Nguyen, VT

Pezzuto, JM

Qiu, SX

Lu, ZZ

机构：

[1] Dept. of Med. Chem. and Pharmacog., College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612-7231

来源：

SYNTHETIC COMMUNICATIONS | 1997年 / 27卷 / 09期

关键词：

D O I：

10.1080/00397919708006099

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Betulin was convert to betulinic acid using two different synthetic routes. The first approach involved an oxidation of betulin using Jones' reagent to betulonic acid and subsequent NaBH4 reduction to betulinic acid. The second approach involved steps utilizing different protecting groups on the alcohol functional groups of betulin and Jones' oxidation to circumvent the isomerization of the secondary alcohol of betulinic acid.

引用

页码：1607 / 1612

页数：6

共 8 条

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