Global government applications of analogues, SARs and QSARs to predict aquatic toxicity, chemical or physical properties, environmental fate parameters and health effects of organic chemicals

被引：43

作者：

Walker, JD

Carlsen, L

Hulzebos, E

Simon-Hettich, B

机构：

[1] US EPA, TSCA, ITC, Washington, DC 20460 USA

[2] Roskilde Univ Ctr, Dept Environm Technol & Social Studies, DK-4000 Roskilde, Denmark

[3] Natl Inst Publ Hlth & Environm, Ctr Substances & Risk, NL-3720 BA Bilthoven, Netherlands

[4] Merck KGAA, Inst Toxicol, D-64271 Darmstadt, Germany

来源：

SAR AND QSAR IN ENVIRONMENTAL RESEARCH | 2002年 / 13卷 / 06期

基金：

美国海洋和大气管理局;

关键词：

SARs; QSARs; government; effects; environmental fate; physicochemical properties;

D O I：

10.1080/1062936021000020062

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Faced with the need to predict physical and chemical properties, environmental fate, ecological effects and health effects of organic chemicals in the absence of experimental data, several Government organizations have been applying analogues, Structure Activity Relationships (SARs) and Quantitative Structure Activity Relationships (QSARs) to develop those predictions. To establish some benchmarks for monitoring future increases in applications of analogues, SARs and QSARs by global Government organizations, this paper describes the current applications of analogues, SARs and QSARs by Australian, Canadian, Danish, European, German, Japanese, Netherlands, and United States Government organizations to predict physical and chemical properties, environmental fate, ecological effects and health effects of organic chemicals.

引用

页码：607 / 616

页数：10

共 45 条

[1] MODE OF ACTION AND THE ASSESSMENT OF CHEMICAL HAZARDS IN THE PRESENCE OF LIMITED DATA - USE OF STRUCTURE-ACTIVITY-RELATIONSHIPS (SAR) UNDER TSCA, SECTION-5 [J].