Beta-glucans as immunostimulant in vertebrates and invertebrates

被引：158

作者：

Soltanian, S. ^{[2
,3
,4
]}

Stuyven, E. ^{[1
]}

Cox, E. ^{[1
]}

Sorgeloos, P. ^{[2
,3
]}

Bossier, P. ^{[2
,3
]}

机构：

[1] Univ Ghent, Fac Vet Med, Immunol Lab, B-9820 Merelbeke, Belgium

[2] Univ Ghent, Dept Anim Prod, Artemia Ref Ctr, B-9000 Ghent, Belgium

[3] Univ Ghent, Lab Aquaculture, B-9000 Ghent, Belgium

[4] Shiraz Univ, Sch Vet Med, Aquat Anim Hlth & Dis Dept, Shiraz, Iran

来源：

CRITICAL REVIEWS IN MICROBIOLOGY | 2009年 / 35卷 / 02期

关键词：

PROTEIN-BOUND POLYSACCHARIDE; SALMO-SALAR L; PATTERN-RECOGNITION RECEPTORS; INNATE IMMUNE-RESPONSE; COAGULATION FACTOR-G; BINDING LECTIN SITE; BLACK TIGER SHRIMP; FACTOR-KAPPA-B; SINGLE-HELICAL SCHIZOPHYLLAN; ONCORHYNCHUS-MYKISS WALBAUM;

D O I：

10.1080/10408410902753746

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Beta-glucans have been studied in animal species, from earthworms to humans. They are a heterogeneous group of glucose polymers found in fungi, plants, some bacteria, and sea weeds. The recognition of conserved microbial structures is a key aspect of metazoan immunity, and beta-glucans are emerging as major target for the recognition of fungal pathogens. However, the receptors and mechanisms by which this is achieved differ significantly between vertebrates and invertebrates. In this review, we will highlight the known receptors for beta-glucans and will discuss the various immune responses they can initiate, with some applications of these products, in both vertebrates and invertebrates.

引用

页码：109 / 138

页数：30

共 401 条

[1] ENHANCED ANTIBODY-RESPONSE IN ATLANTIC SALMON (SALMO-SALAR L) TO AEROMONAS-SALMONICIDA CELL-WALL ANTIGENS USING A BACTERIN CONTAINING BETA-1, 3-M-GLUCAN AS ADJUVANT [J].