Intermediate phenotypes and genetic mechanisms of psychiatric disorders

被引：836

作者：

Meyer-Lindenberg, Andreas ^{[1
]}

Weinberger, Daniel R. ^{[1
]}

机构：

[1] NIMH, Unit Syst Neurosci Psychiat, Clin Brain Disorders Branch, Gene Cognit & Psychosis Program,NIH,Dept Hlth & H, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2006年 / 7卷 / 10期

关键词：

D O I：

10.1038/nrn1993

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Genes are major contributors to many psychiatric diseases, but their mechanisms of action have long seemed elusive. The intermediate phenotype concept represents a strategy for characterizing the neural systems affected by risk gene variants to elucidate quantitative, mechanistic aspects of brain function implicated in psychiatric disease. Using imaging genetics as an example, we illustrate recent advances, challenges and implications of linking genes to structural and functional variation in brain systems related to cognition and emotion.

引用

收藏

页码：818 / 827

页数：10

相关论文

共 96 条

[1]

Akil M, 2003, J NEUROSCI, V23, P2008

[2] PARALLEL ORGANIZATION OF FUNCTIONALLY SEGREGATED CIRCUITS LINKING BASAL GANGLIA AND CORTEX [J].

ALEXANDER, GE ;

DELONG, MR ;

STRICK, PL .

ANNUAL REVIEW OF NEUROSCIENCE, 1986, 9 :357-381

[3]

Almasy L, 2001, AM J MED GENET, V105, P42, DOI 10.1002/1096-8628(20010108)105:1<42::AID-AJMG1055>3.3.CO

[4]

2-0

[5] Autism as a disorder of neural information processing: directions for research and targets for therapy [J].

Belmonte, MK ;

Cook, EH ;

Anderson, GM ;

Rubenstein, JLR ;

Greenough, WT ;

Beckel-Mitchener, A ;

Courchesne, E ;

Boulanger, LM ;

Powell, SB ;

Levitt, PR ;

Perry, EK ;

Jiang, YH ;

DeLorey, TM ;

Tierney, E .

MOLECULAR PSYCHIATRY, 2004, 9 (07) :646-663

[6] Altered development of prefrontal neurons in rhesus monkeys with neonatal mesial temporo-limbic lesions: A proton magnetic resonance spectroscopic imaging study [J].

Bertolino, A ;

Saunders, RC ;

Mattay, VS ;

Bachevalier, J ;

Frank, JA ;

Weinberger, DR .

CEREBRAL CORTEX, 1997, 7 (08) :740-748

[7] Prefrontal-hippocampal coupling during memory processing is modulated by COMT Val158met genotype [J].

Bertolino, Alessandro ;

Rubino, Valeria ;

Sarnbataro, Fabio ;

Blasi, Giuseppe ;

Latorre, Valeria ;

Fazio, Leonardo ;

Caforio, Grazia ;

Petruzzella, Vittoria ;

Kolachana, Bhaskar ;

Hariri, Ahmad ;

Meyer-Lindenberg, Andreas ;

Nardini, Marcello ;

Weinberger, Daniel R. ;

Scarabino, Tommaso .

BIOLOGICAL PSYCHIATRY, 2006, 60 (11) :1250-1258

[8] A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain [J].

Bray, NJ ;

Buckland, PR ;

Williams, NM ;

Williams, HJ ;

Norton, N ;

Owen, MJ ;

O'Donovan, MC .

AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 73 (01) :152-161

[9] A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity [J].

Brown, SM ;

Peet, E ;

Manuck, SB ;

Williamson, DE ;

Dahl, RE ;

Ferrell, RE ;

Hariri, AR .

MOLECULAR PSYCHIATRY, 2005, 10 (09) :884-888

[10] Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia [J].

Callicott, JH ;

Straub, RE ;

Pezawas, L ;

Egan, MF ;

Mattay, VS ;

Hariri, AR ;

Verchinski, BA ;

Meyer-Lindenberg, A ;

Balkissoon, R ;

Kolachana, B ;

Goldberg, TE ;

Weinberger, DR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (24) :8627-8632

← 1 2 3 4 5 6 7 8 9 10 →