Comparison of three methods for pharmacokinetic screening in rats using LC-MS-MS

被引：3

作者：

Briem, S ^{[1
]}

Eklund, E

Williams, G

Brunvoll, J

机构：

[1] AstraZeneca R&D Sodertalje, Dept DMPK Res, S-15185 Sodertalje, Sweden

[2] Univ Tromso, Inst Pharm, N-9001 Tromso, Norway

来源：

CHROMATOGRAPHIA | 2002年 / 55卷 / Suppl 1期

关键词：

liquid chromatography; mass spectrometry; sample preparation; ion suppression; pharmacokinetic screening;

D O I：

10.1007/BF02493350

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The influence of sample preparation on ion suppression is studied using the model compounds ropivaccine and 3OH-ropivocaine. Three sample preparation techniques are assessed: Solid Phase Extraction (SPE), Direct Dilution and Protein Precipitation. Although requiring more method development and being more time-consuming than the two alternative preparation techniques, SPE had a greater impact on reducing ion suppression.

引用

页码：S35 / S39

页数：5

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