Direct access to enantiomerically enriched α-amino phosphonic acid derivatives by organocatalytic asymmetric hydrophosphonylation of imines

被引：136

作者：

Pettersen, Daniel ^{[1
]}

Marcolini, Mauro ^{[1
]}

Bernardi, Luca ^{[1
]}

Fini, Francesco ^{[1
]}

Herrera, Raquel P. ^{[1
]}

Sgarzani, Valentina ^{[1
]}

Ricci, Alfredo ^{[1
]}

机构：

[1] Univ Bologna, Dept Organ Chem A Mangini, I-40136 Bologna, Italy

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 16期

关键词：

D O I：

10.1021/jo060708h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient organocatalytic enantioselective hydrophosphonylation of imines to enantiomerically enriched alpha-amino phosphonates is reported. By using 10 mol % of quinine as the catalyst in the enantioselective addition of diethyl phosphite to N-Boc protected imines, alpha-amino phosphonates are obtained in moderate to good yields and with up to 94% ee.

引用

页码：6269 / 6272

页数：4

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