A change of strategy in the war on cancer

被引:276
作者
Gatenby, Robert A. [1 ,2 ]
机构
[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Radiol, Tampa, FL 33612 USA
[2] H Lee Moffitt Canc Ctr & Res Inst, Dept Integrated Math Oncol, Tampa, FL 33612 USA
关键词
RIBONUCLEOTIDE REDUCTASE; CELL-LINES; RESISTANCE;
D O I
10.1038/459508a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Patients and politicians anxiously await and increasingly demand a 'cure' for cancer. But trying to control the disease may prove a better plan than striving to cure it, says Robert A. Gatenby.
引用
收藏
页码:508 / 509
页数:2
相关论文
共 5 条
[1]   An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines [J].
Davidson, JD ;
Ma, LD ;
Flagella, M ;
Geeganage, S ;
Gelbert, LM ;
Slapak, CA .
CANCER RESEARCH, 2004, 64 (11) :3761-3766
[2]  
GATENBY RA, CANC RES IN PRESS
[3]   Suppression of lung tumor formation by the regulatory subunit of ribonucleotide reductase [J].
Gautam, Ashish ;
Bepler, Gerold .
CANCER RESEARCH, 2006, 66 (13) :6497-6502
[4]   Pretherapy nuclear factor-κB status, chemoradiation resistance, and metastatic progression in esophageal carcinoma [J].
Izzo, Julie G. ;
Correa, Arlene M. ;
Wu, Tsung-Teh ;
Malhotra, Usha ;
Chao, Clifford K. S. ;
Luthra, Rajyalakshmi ;
Ensor, Joe ;
Dekovich, Alexander ;
Liao, Zhongxing ;
Hittelman, Walter N. ;
Aggarwal, Bharat B. ;
Ajani, Jaffer A. .
MOLECULAR CANCER THERAPEUTICS, 2006, 5 (11) :2844-2850
[5]   Changes associated with the development of resistance to imatinib (STI571) in two leukemia cell lines expressing p210 Bcr/Abl protein [J].
Scappini, B ;
Gatto, S ;
Onida, F ;
Ricci, C ;
Divoky, V ;
Wierda, WG ;
Andreeff, M ;
Dong, L ;
Hayes, K ;
Verstovsek, S ;
Kantarjian, HM ;
Beran, M .
CANCER, 2004, 100 (07) :1459-1471