Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

被引：1934

作者：

Garten, Rebecca J. ^{[2
]}

Davis, C. Todd ^{[2
]}

Russell, Colin A. ^{[1
,3
]}

Shu, Bo ^{[2
]}

Lindstrom, Stephen ^{[2
]}

Balish, Amanda ^{[2
]}

Sessions, Wendy M. ^{[2
]}

Xu, Xiyan ^{[2
]}

Skepner, Eugene ^{[1
,2
]}

Deyde, Varough ^{[2
]}

Okomo-Adhiambo, Margaret ^{[2
]}

Gubareva, Larisa ^{[2
]}

Barnes, John ^{[2
]}

Smith, Catherine B. ^{[2
]}

Emery, Shannon L. ^{[2
]}

Hillman, Michael J. ^{[2
]}

Rivailler, Pierre ^{[2
]}

Smagala, James ^{[2
]}

de Graaf, Miranda ^{[1
,4
]}

Burke, David F. ^{[1
]}

Fouchier, Ron A. M. ^{[4
]}

Pappas, Claudia ^{[2
]}

Alpuche-Aranda, Celia M. ^{[5
]}

Lopez-Gatell, Hugo ^{[5
]}

Olivera, Hiram ^{[5
]}

Lopez, Irma ^{[5
]}

Myers, Christopher A. ^{[6
]}

Faix, Dennis ^{[6
]}

Blair, Patrick J. ^{[6
]}

Yu, Cindy ^{[7
]}

Keene, Kimberly M. ^{[8
]}

Dotson, P. David, Jr. ^{[9
]}

Boxrud, David ^{[10
]}

Sambol, Anthony R. ^{[11
]}

Abid, Syed H. ^{[12
]}

George, Kirsten St. ^{[13
]}

Bannerman, Tammy ^{[14
]}

Moore, Amanda L. ^{[15
]}

Stringer, David J. ^{[16
]}

Blevins, Patricia ^{[17
]}

Demmler-Harrison, Gail J. ^{[18
]}

Ginsberg, Michele ^{[19
]}

Kriner, Paula ^{[20
]}

Waterman, Steve ^{[21
]}

Smole, Sandra ^{[22
]}

Guevara, Hugo F. ^{[2
,23
]}

Belongia, Edward A. ^{[2
,24
]}

Clark, Patricia A. ^{[2
,25
]}

Beatrice, Sara T. ^{[2
,26
]}

Donis, Ruben ^{[2
]}

机构：

[1] Univ Cambridge, Dept Zool, Cambridge CB2 3EJ, England

[2] Ctr Dis Control & Prevent CDC, WHO, Collaborating Ctr Influenza, Atlanta, GA 30333 USA

[3] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA

[4] Erasmus MC, Dept Virol, NL-3000 CA Rotterdam, Netherlands

[5] InDRE Prolongac Carpio, Mexico City 11340, DF, Mexico

[6] USN, Hlth Res Ctr, San Diego, CA 92152 USA

[7] Arizona State Publ Hlth Lab, Phoenix, AZ 85007 USA

[8] Colorado Dept Publ Hlth & Environm, Denver, CO 80230 USA

[9] Indiana State Dept Hlth Labs, Indianapolis, IN 46202 USA

[10] Minnesota Dept Hlth, Publ Hlth Lab, St Paul, MN 55164 USA

[11] Nebraska Publ Hlth Lab, Omaha, NE 68198 USA

[12] Westchester Cty Dept Labs & Res Publ Hlth Labs, Valhalla, NY 10595 USA

[13] New York State Dept Hlth, Wadsworth Ctr, Slingerlands, NY USA

[14] Ohio Dept Hlth Lab, Reynoldsburg, OH USA

[15] S Carolina Dept Hlth & Environm Control, Columbia, SC 29223 USA

[16] Dallas Cty Hlth & Human Serv, Dallas, TX 75207 USA

[17] San Antonio Metro Hlth Dist, Brooks City Base, TX 78235 USA

[18] Texas Childrens Hosp, Diagnost Virol Lab, Houston, TX 77030 USA

[19] San Diego Publ Hlth Lab, San Diego, CA 92186 USA

[20] Imperial Cty Publ Hlth Dept, El Centro, CA 92243 USA

[21] CDC, Border Infect Dis Surveillance Project, Atlanta, GA 30333 USA

[22] Massachusetts Dept Publ Hlth, William A Hinton State Lab Inst, Jamaica Plain, MA 02130 USA

[23] Calif Dept Publ Hlth, Viral & Rickettsial Dis Lab, Richmond, CA 94804 USA

[24] Marshfield Clin Fdn Med Res & Educ, Marshfield, WI 54449 USA

[25] Michigan Dept Community Hlth, Lansing, MI 48906 USA

[26] NYU, Dept Hlth & Mental Hyg, Publ Hlth Lab, New York, NY 10016 USA

来源：

SCIENCE | 2009年 / 325卷 / 5937期

关键词：

A VIRUS; PHYLOGENETIC ANALYSIS; UNITED-STATES; NORTH-AMERICA; EVOLUTION; PIGS; PATHOGENICITY; TRANSMISSION; EMERGENCE; INFECTION;

D O I：

10.1126/science.1176225

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans. The lack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period. Its low genetic diversity suggests that the introduction into humans was a single event or multiple events of similar viruses. Molecular markers predictive of adaptation to humans are not currently present in 2009 A(H1N1) viruses, suggesting that previously unrecognized molecular determinants could be responsible for the transmission among humans. Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1).

引用

页码：197 / 201

页数：5

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