Synthesis and analytical characterization of RNA-polyethylene glycol conjugates

被引：14

作者：

Jaschke, A

Bald, R

Nordhoff, E

Hillenkamp, F

Cech, D

Erdmann, VA

Furste, JP

机构：

[1] HUMBOLDT UNIV BERLIN,INST CHEM,D-10099 BERLIN,GERMANY

[2] FREE UNIV BERLIN,INST BIOCHEM,D-14195 BERLIN,GERMANY

[3] UNIV MUNSTER,INST MED PHYS & BIOPHYS,D-48149 MUNSTER,GERMANY

来源：

NUCLEOSIDES & NUCLEOTIDES | 1996年 / 15卷 / 09期

关键词：

D O I：

10.1080/07328319608002451

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polyethylene glycols with degrees of polymerization from 5 to more than 100 were incorporated into synthetic oligoribonucleotides by automated solid phase synthesis at 3'-terminal, 5'-terminal and internal positions. The conjugates were characterized by chromatographic, electrophoretic and mass-spectrometric methods. The influence of coupling site, polymer size and number of coupled polymers per oligonucleotide on the molecular properties of the conjugates is investigated.

引用

页码：1519 / 1529

页数：11

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