Voltammetric behavior of adriamycin and its determination at Ni ion-implanted electrode

With a Ni ion-implanted glassy carbon electrode (GCE) as the working electrode in 0.1 mol/l HAc-NaAc (pH=4.62) solution, a sensitive reductive wave of adriamycin was obtained by linear-sweep voltammetry. The peak potential was -0.55 V (vs. SCE). The peak current was proportional to the concentration of adriamycin over the range of 5.2x10(-7) - 1.0x10(-5) mol/l and the detection limit was 2.7x10(-7) mol/l. The behavior of the reduction wave was studied and the wave was applied to the determination of adriamycin in urine. The reduction process was quasi-reversible, AES and XPS experiments showed that Ni was surely implanted into the surface of the GCE, and the implanted Ni at the GCE improved the electrocatalytic activity.