Solid phase synthesis of peptidoglycan monomers for the generation of a combinatorial library

被引：10

作者：

Chan, TY

Chen, A

Allanson, N

Chen, R

Liu, DS

Sofia, MJ

机构：

[1] Transcell Technologies, Inc., Monmouth Junction, NJ 08852

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 45期

关键词：

D O I：

10.1016/0040-4039(96)01849-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Solid phase synthesis of peptidoglycan monomers was conducted by coupling the corresponding lipid-hearing glycocarboxylic acids to resin-bound peptides. The efficiency of coupling reagents was found to be in descending order of HATU>HBTU>PyBOP>EEDQ. There was no obvious difference in coupling yield between conducting the solid phase synthesis on polystyrene resins or on polyethylene glycol grafted polystyrene resins. Copyright (C) 1996 Elsevier Science Ltd

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页码：8097 / 8100

页数：4

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