Exogenously incorporated ketocarotenoids in large unilamellar vesicles. Protective activity against peroxidation

被引：31

作者：

Rengel, D ^{[1
]}

Diez-Navajas, A ^{[1
]}

Serna-Rico, A ^{[1
]}

Veiga, P ^{[1
]}

Muga, A ^{[1
]}

Milicua, JCG ^{[1
]}

机构：

[1] Univ Basque Country, Dept Biochem & Mol Biol, Bilbao 48080, Spain

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2000年 / 1463卷 / 01期

关键词：

carotenoid; liposome; antioxidant; lipid peroxidation; lipid-carotenoid interaction;

D O I：

10.1016/S0005-2736(99)00194-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ability of astaxanthin and canthaxanthin as chain-breaking antioxidants was studied in Cu2+-initiated peroxidation of phosphatidylcholine large unilamellar vesicles (LUVs). Both carotenoids increased the lag period that precedes the maximum rate of lipid peroxidation, though astaxanthin showed stronger activity. For these experiments, different amounts of xanthophylls were exogenously added to previously made LUVs, non-incorporated pigment being afterwards removed. Differential scanning calorimetry assays with L-beta,gamma-dimyristoyl-alpha-phosphatidylcholine LUVs demonstrated that xanthophylls incorporated as described interact with the lipid matrix becoming interspersed among the phospholipid molecules. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：179 / 187

页数：9

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