Varicella-zoster virus proteins in skin lesions: Implications for a novel role of ORF29p in chickenpox

被引：13

作者：

Annunziato, PW

Lungu, O

Panagiotidis, C

Zhang, JH

Silvers, DN

Gershon, AA

Silverstein, SJ

机构：

[1] Columbia Univ Coll Phys & Surg, Dept Pediat, New York, NY 10032 USA

[2] Columbia Univ Coll Phys & Surg, Dept Microbiol, New York, NY 10032 USA

[3] Columbia Univ Coll Phys & Surg, Dept Dermatol & Pathol, New York, NY 10032 USA

来源：

JOURNAL OF VIROLOGY | 2000年 / 74卷 / 04期

关键词：

D O I：

10.1128/JVI.74.4.2005-2010.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Skin biopsy samples from varicella-zoster virus (VZV)-infected patients examined by immunohistochemistry demonstrated VZV replication in nonepithelial cell types. ORF29p, a nonstructural nuclear protein, was found in nerves of two of six patients with chickenpox. In tissue culture, ORF29p was secreted by Vi;V-infected fibroblasts. Extracellular ORF29p can be taken up through endocytosis by human neurons, implying a novel role for this protein in pathogenesis.

引用

页码：2005 / 2010

页数：6

共 30 条

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