A radiation hybrid map of bovine chromosome one

被引:24
作者
Rexroad, CE
Schlapfer, JS
Yang, Y
Harlizius, B
Womack, JE [1 ]
机构
[1] Texas A&M Univ, Inst Biosci & Technol, Dept Vet Pathobiol, College Stn, TX 77843 USA
[2] Texas A&M Univ, Inst Biosci & Technol, Ctr Anim Genet, College Stn, TX 77843 USA
[3] Tierarztlichen Hsch Hannover, Inst Genet & Anim Breeding, D-30545 Hannover, Germany
关键词
radiation hybrid mapping; cattle;
D O I
10.1046/j.1365-2052.1999.00504.x
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
Radiation hybrid (RH) mapping has proven to be an extremely powerful approach to constructing high density maps of human chromosomes and is experiencing increased use in other animals, including cattle. A 5000 rad bovine whole-genome radiation hybrid panel was recently constructed in order to integrate existing cattle linkage maps with evolutionarily conserved genes and provide high resolution comparative maps relative to humans and mice. We utilized this panel to construct a 19 marker framework map of bovine chromosome 1 (BTA1), which included 8 Type 1 loci and 11 Type II loci ordered with at least 1000:1 odds. A 35 marker comprehensive map including 15 Type I loci and 20 Type II loci was also produced. Of the 15 Type I loci ordered on the comprehensive map, three are ordered on HSA3 and five are ordered in three blocks on HSA21 on the human cytogenetic maps.
引用
收藏
页码:325 / 332
页数:8
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