Analysis of the cellular functions of Escherichia coli operons and their conservation in Bacillus subtilis

被引：33

作者：

de Daruvar, A

Collado-Vides, J

Valencia, A ^{[1
]}

机构：

[1] CSIC, CNB, Prot Design Grp, E-28049 Madrid, Spain

[2] CSIC, INTA, Ctr AstroBiol, E-28049 Madrid, Spain

[3] Univ Nacl Autonoma Mexico, Ctr Invest Fijac Nitrogeno, Program Computat Biol, Cuernavaca, Morelos, Mexico

[4] LION BIOSCI AG, Heidelberg, Germany

来源：

JOURNAL OF MOLECULAR EVOLUTION | 2002年 / 55卷 / 02期

关键词：

genome comparisons; gene order; operons; Escherichia coli; Bacillus subtilis; classes of cell function;

D O I：

10.1007/s00239-002-2317-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The common assumption of operons as composed of genes that cooperate in a biological process is confirmed here by showing that Escherichia coli operons tend to be composed of genes that belong to the same general class of cellular function. Furthermore, the comparison between the genomic organization of E. coli and that of Bacillus subtilis shows that the genes that are homologous to genes that belong to experimentally characterized E. coli operons tend to cluster in neighboring regions of the genome. This tendency is greater for the subset of E. coli operons whose genes belong to a single functional class. These observations indicate strong evolutionary pressure that, translated into functional constraints, leads to the inclusion of many essential functions in conserved operons and clusters in these two distant species.

引用

页码：211 / 221

页数：11

共 32 条

[1] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].