GHRH and IL1β increase cytoplasmic Ca2+ levels in cultured hypothalamic GABAergic neurons

被引：47

作者：

De, A

Churchill, L

Obal, F

Simasko, SM

Krueger, JM ^{[1
]}

机构：

[1] Washington State Univ, Program Neurosci, Dept VCAPP, Pullman, WA 99164 USA

[2] Univ Szeged, Dept Physiol, A Szent Gyorgyi Med Ctr, Szeged, Hungary

来源：

BRAIN RESEARCH | 2002年 / 949卷 / 1-2期

关键词：

sleep; GABA; GAD; cytokines;

D O I：

10.1016/S0006-8993(02)03157-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

GHRH and IL1beta regulate steep via the hypothalamus. However, actions of these substances on neurons are poorly understood. In this study, we found both GHRH (100 nM) and IL1beta (1.2 pM) acutely increased cytosolic Ca2+ in 7.6 and 4.0% of cultured hypothalamic neurons tested, respectively, and 1.2% of neurons responded to both. The neurons that responded were mostly GABAergic (96, 81, and 100%, for GHRH, IL1beta, and dual-responsive neurons, respectively). (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：209 / 212

页数：4

共 26 条

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