Efficacy of β-lactams for treating experimentally induced pneumonia due to a carbapenem-hydrolyzing metallo-β-lactamase-producing strain of Pseudomonas aeruginosa

被引：34

作者：

Bellais, S

Mimoz, O

Léotard, S

Jacolot, A

Petitjean, O

Nordmann, P

机构：

[1] Hop Bicetre, Serv Bacteriol Virol Hyg, Assistance Publ Hop Paris, Fac Med Paris Sud, F-94275 Le Kremlin Bicetre, France

[2] Univ Miletrie, Ctr Hosp, Dept Anesthesie & Reanimat Chirurg, F-86021 Poitiers, France

[3] Fac Med Paris Nord, Ctr Rech & Pathol Infect & Trop, F-93009 Bobigny, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 06期

关键词：

D O I：

10.1128/AAC.46.6.2032-2034.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A rat pneumonia model was established with a Pseudomonas aeruginosa strain that produced the plasmid-encoded metallocarbapenemase VIM-2. A significant decrease in lung bacterial titers was observed Mien imipenem, cefepime, ceftazidime, and piperacillin-tazobactam were given at the highest doses recommended for humans, despite their high MICs. Aztreonam at high doses produced a similar decrease in bacterial titers.

引用

页码：2032 / 2034

页数：3

共 22 条

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