A new family of cyclophilins with an RNA recognition motif that interact with members of the trx/MLL protein family in Drosophila and human cells

被引：21

作者：

Anderson, M

Fair, K

Amero, S

Nelson, S

Harte, PJ

Diaz, MO

机构：

[1] Loyola Univ, Med Ctr, Stritch Sch Med, Canc Ctr,Dept Med, Maywood, IL 60153 USA

[2] Loyola Univ, Med Ctr, Stritch Sch Med, Dept Microbiol & Immunol, Maywood, IL 60153 USA

[3] Case Western Reserve Univ, Sch Med, Dept Genet, Cleveland, OH 44106 USA

来源：

DEVELOPMENT GENES AND EVOLUTION | 2002年 / 212卷 / 03期

关键词：

cyclophilin; RNA recognition motif (RRM) domain; trithorax; PHD finger; Hox genes;

D O I：

10.1007/s00427-002-0213-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A new family of cyclophilins with an RNA recognition motif (RRM) has members in vertebrates, roundworms and flatworms. We have identified a Drosophila cyclophilin, Dcyp33, with a high degree of amino acid sequence identity and similarity with other members of the family. Dcyp33 interacts through its RRM domain with the third PHD finger of trithorax. This interaction is conserved in the human homologues of these proteins, Cyp33 and MLL. Over expression of Dcyp33 in Drosophila SL1 cells results in down-regulation of AbdominalB Hox gene expression, mirroring the effect of human Cyp33 on the expression of human HOX genes.

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页码：107 / 113

页数：7

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