Mapping autoimmunity genes

被引：67

作者：

Griffiths, MM

Encinas, JA

Remmers, EF

Kuchroo, VK

Wilder, RL

机构：

[1] Univ Utah, Sch Med, Dept Med, Vet Affairs Med Ctr,Res Serv, Salt Lake City, UT 84132 USA

[2] Brigham & Womens Hosp, Dept Med, Ctr Neurol Dis, Boston, MA 02115 USA

[3] Bayer Yakuhin Ltd, Res Ctr, Kyoto 6190216, Japan

[4] NIAMSD, Inflammatory Joint Dis Sect, Arthrit & Rheumatism Branch, NIH, Bethesda, MD 20892 USA

[5] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0952-7915(99)00038-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rat and mouse models for the major human autoimmune/inflammatory diseases are under intense genetic scrutiny. Genome-wide linkage studies reveal that each model is regulated by multiple genetic loci, Many of these loci colocalize to homologous genomic regions associated with several different autoimmune diseases of mice, rats and humans. Candidate genes are being identified, Polymorphic alleles associated with these chromosomal segments may represent predisposing genetic elements common to a number of human diseases with very different clinical presentations.

引用

页码：689 / 700

页数：12

共 92 条

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