Nonenzymatic kinetic resolution of 1,2-diols catalyzed by an organotin compound

被引：67

作者：

Iwasaki, F

Maki, T

Nakashima, W

Onomura, O

Matsumura, Y

机构：

[1] Nagasaki Univ, Fac Pharmaceut Sci, Nagasaki 8528131, Japan

[2] Kyushu Univ, Inst Fundamental Res Organ Chem, Higashi Ku, Fukuoka 8128581, Japan

[3] Tokuyama Corp, Tsukuba Res Lab, Tsukuba, Ibaraki 3004247, Japan

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 07期

关键词：

D O I：

10.1021/ol9908373

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A new nonenzymatic kinetic resolution method of 1,2-diols 1 using chiral organotin catalyst A with benzoyl chloride was developed. A remarkable effect due to an inorganic base such as sodium carbonate and a small portion of water on the ee of the main products 2 was observed. The reaction showed high enantio- and chemoselectivities to 1,2-diols 1.

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页码：969 / 972

页数：4

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