Treatment monitoring and response prediction with proton MR spectroscopy in AD

被引：60

作者：

Jessen, F.

Traeber, F.

Freymann, K.

Maier, W.

Schild, H. H.

Block, W.

机构：

[1] Univ Bonn, Dept Psychiat, D-53105 Bonn, Germany

[2] Univ Bonn, Dept Radiol, D-53105 Bonn, Germany

来源：

NEUROLOGY | 2006年 / 67卷 / 03期

关键词：

D O I：

10.1212/01.wnl.0000228218.68451.31

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In this proton magnetic resonance spectroscopy ( H-1-MRS) study, the authors correlated cognitive improvement after 3 months of treatment with donepezil with changes of N-acetylaspartate ( NAA) level and NAA/Creatine ( Cr) ratio in the medial temporal and parietal lobe of 17 patients with Alzheimer disease. Treatment response was associated with an increase of NAA and NAA/Cr in the parietal lobe. Low baseline NAA/Cr in the parietal lobe predicted positive treatment outcome.

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页码：528 / 530

页数：3

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