Application of pressurized liquid extraction technology to pharmaceutical solid dosage form analysis

被引：14

作者：

Hoang, TH ^{[1
]}

Farkas, R ^{[1
]}

Wells, C ^{[1
]}

McClintock, S ^{[1
]}

Di Maso, M ^{[1
]}

机构：

[1] Merck Frosst Canada & Co, Dept Pharmaceut Res & Dev, Pointe Claire, PQ H9R 4P8, Canada

来源：

JOURNAL OF CHROMATOGRAPHY A | 2002年 / 968卷 / 1-2期

关键词：

pressurized liquid extraction; extraction method; pharmaceutical analysis; montelukast sodium;

D O I：

10.1016/S0021-9673(02)00956-1

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The technique of pressurized liquid extraction has been evaluated for the extraction of active ingredients from pharmaceutical dosage forms using montelukast sodium oral chewable tablets as a model. The extraction method was optimized for the number of extraction cycles, extraction time, extraction solvent composition and temperature. Samples were extracted using two cycles of water for 2 min with a cell temperature of 40 degreesC and a pressure of 1.0x10(4) kPa, to disintegrate the tablet, followed by three cycles of methanol for 3 min at 70 degreesC and 1.0x10(4) kPa, to solubilize montelukast sodium. The method demonstrated an extraction efficiency of 98.2% of label claim and an RSD of 1.3% (n=10), as compared to 97.6% and an RSD of 0.9% obtained using a validated mechanical extraction method. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：257 / 261

页数：5

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