A nine-codon deletion mutation in the cytomegalovirus UL97 phosphotransferase gene confers resistance to ganciclovir

被引：28

作者：

Chou, SW

Meichsner, CL

机构：

[1] Oregon Hlth Sci Univ, Vet Affairs Med Ctr, Med & Res Serv, Portland, OR 97201 USA

[2] Oregon Hlth Sci Univ, Vet Affairs Med Ctr, Div Infect Dis, Portland, OR 97201 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 01期

关键词：

D O I：

10.1128/AAC.44.1.183-185.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A deletion mutation (codons 595 to 603) in the cytomegalovirus (CMV) UL97 gene was recently reported after sequence analysis of leukocyte DNA from a patient receiving ganciclovir. The corresponding viral phenotype was examined by transfer of this mutation to a laboratory CMV strain (strain Towne). The recombinant virus was resistant to ganciclovir (8.4-fold increase in the 50% inhibitory concentration), was sensitive to foscarnet, and replicated normally in cell culture.

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页码：183 / 185

页数：3

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