Regression of gastric MALT lymphoma after eradication of Helicobacter pylori is predicted by endosonographic staging

被引:217
作者
Sackmann, M
Morgner, A
Rudolph, B
Neubauer, A
Thiede, C
Schulz, H
Kraemer, W
Boersch, G
Rohde, P
Seifert, E
Stolte, M
Bayerdoerffer, E
Allmendinger, D
Baestlein, E
Baghdadi, F
Berges, W
Bode, J
Chalybaeus, C
Diehl, HG
Frevel, M
Gieseler, U
Habbig, J
Heidegger, AE
Hotz, J
Huelskath, H
Itzen, WH
Judmaier, G
Kolthoff, H
Krautter, H
Kuehner, W
Manegold, CE
Pechlivanis, C
Puerner, K
Schloemann, L
Schmitz, L
Schmitz, R
Stadelmann, O
Stein, H
Stoian, L
Stumpf, J
Thilo, A
Trump, F
Wambach, G
Weismueller, J
Zellman, A
机构
[1] UNIV MUNICH,DEPT MED 2,D-81366 MUNICH,GERMANY
[2] UNIV MAGDEBURG,D-39106 MAGDEBURG,GERMANY
[3] TECH UNIV DRESDEN,DEPT MED 1,D-8027 DRESDEN,GERMANY
[4] ELIZABETH HOSP,DIV GASTROENTEROL,ESSEN,GERMANY
[5] MARIEN HOSP,DEPT MED,HAMM,GERMANY
[6] MUNICIPAL KLINIKUM KEMPERHOF,DEPT MED 1,KOBLENZ,GERMANY
[7] INST PATHOL,BAYREUTH,GERMANY
[8] ROBERT BOSCH KRANKENHAUS,STUTTGART,GERMANY
[9] STAEDT KRANKENHAUS KEMPERHOF,KOBLENZ,GERMANY
[10] CLEMENS AUGUST KRANKENHAUS,BITBURG,GERMANY
[11] DIAKONIEKRANKENHAUS SPEYER,SPEYER,GERMANY
[12] KREISKRANKENHAUS BERCHTESGADEN,BERCHTESGADEN,GERMANY
[13] ALLGEMEINES KRANKENHAUS CELLE,CELLE,GERMANY
[14] EVANGEL KRANKENHAUS,MUEHLACKER,GERMANY
[15] UNIV KLINIKUM,INNSBRUCK,AUSTRIA
[16] KREISKRANKENHAUS EBERSBERG,EBERSBERG,GERMANY
[17] KREISKRANKENHAUS HERTEN,HERTEN,GERMANY
[18] EVANGEL KRANKENHAUS,BERGISCH GLADBAC,GERMANY
[19] KRANKENHAUS MARIENHOF,KOBLENZ,GERMANY
[20] KREISKRANKENHAUS WEISSENBURG,WEISSENBURG,GERMANY
[21] KREISKRANKENHAUS SCHESSLITZ,SCHESSLITZ,GERMANY
[22] KREISKRANKENHAUS WEISSENBURG,GROSSBURGWEDEL,GERMANY
[23] KREISKRANKENHAUS GROSSBURGWEDEL,GROSSBURGWEDEL,GERMANY
[24] KREISKRANKENHAUS PEGNITZ,PEGNITZ,GERMANY
[25] ST ELIZABETH HOSP,HERTEN,GERMANY
关键词
D O I
10.1053/gast.1997.v113.pm9322502
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background & Aims: Recent studies suggest that eradication of Helicobacter pylori may result in complete regression of low-grade lymphoma of the gastric mucosa-associated lymphoid tissue (MALT), Which patients benefit from this treatment is unknown. The aim of this study was to prospectively study whether staging by echoendoscopy predicts the outcome of treatment of MALT lymphoma by eradication of H. pylori. Methods: Twenty-two patients positive for H. pylori with low-grade gastric B-cell MALT lymphoma were examined by echoendoscopy at the time of diagnosis, Treatment for H. pylori consisted of a 2-week course of oral I omeprazole and amoxicillin. Patients were followed up by endoscopy and biopsy. Results: H. pylori was eradicated in all patients, Complete regression of MALT lymphoma was observed in 12 patients (54%), partial regression in 5 patients (23%), and no response in 5 patients (23%) during follow-up, Twelve of 14 patients with lymphoma restricted to the mucosa or submucosa (stage E-I-1) at echoendoscopy, but none of the 10 patients with higher stage (P < 0.01), showed complete regression of MALT lymphoma. In stage E-I-1 patients, the probability of complete regression of lymphoma was 60% at 6, 79% at 12, and reached 100% at 14 months, respectively, Conclusions: Staging of gastric low-grade MALT lymphomas by endoscopic ultrasonography allows prediction of the response to therapy by eradication of H. pylori.
引用
收藏
页码:1087 / 1090
页数:4
相关论文
共 34 条
[1]   REGRESSION OF PRIMARY GASTRIC LYMPHOMA OF MUCOSA-ASSOCIATED LYMPHOID-TISSUE TYPE AFTER CURE OF HELICOBACTER-PYLORI INFECTION [J].
BAYERDORFFER, E ;
NEUBAUER, A ;
RUDOLPH, B ;
THIEDE, C ;
LEHN, N ;
EIDT, S ;
STOLTE, M .
LANCET, 1995, 345 (8965) :1591-1594
[2]   RESOLUTION OF HELICOBACTER-PYLORI-ASSOCIATED GASTRIC LYMPHOPROLIFERATIVE DISEASE IN A CHILD [J].
BLECKER, U ;
MCKEITHAN, TW ;
HART, J ;
KIRSCHNER, BS .
GASTROENTEROLOGY, 1995, 109 (03) :973-977
[3]   HELICOBACTER-PYLORI REINFECTION AND RAPID RELAPSE OF LOW-GRADE B-CELL GASTRIC LYMPHOMA [J].
CAMMAROTA, G ;
MONTALTO, M ;
TURSI, A ;
VECCHIO, FM ;
FEDELI, G ;
GASBARRINI, G .
LANCET, 1995, 345 (8943) :192-192
[4]   PREVENTION AND TREATMENT OF LOW-GRADE B-CELL PRIMARY GASTRIC LYMPHOMA BY ANTI-H-PYLORI THERAPY [J].
CAMMAROTA, G ;
TURSI, A ;
MONTALTO, M ;
PAPA, A ;
BRANCA, G ;
VECCHIO, FM ;
RENZI, C ;
VERZI, A ;
ARMUZZI, A ;
PRETOLANI, S ;
FEDELI, G ;
GASBARRINI, G .
JOURNAL OF CLINICAL GASTROENTEROLOGY, 1995, 21 (02) :118-122
[5]  
CARBONE PP, 1971, CANCER RES, V31, P1860
[6]   PRIMARY B-CELL GASTRIC LYMPHOMA - A CLINICOPATHOLOGICAL STUDY OF 145 PATIENTS [J].
COGLIATTI, SB ;
SCHMID, U ;
SCHUMACHER, U ;
ECKERT, F ;
HANSMANN, ML ;
HEDDERICH, J ;
TAKAHASHI, H ;
LENNERT, K .
GASTROENTEROLOGY, 1991, 101 (05) :1159-1170
[7]  
DIMAGNO EP, 1980, LANCET, V1, P629
[8]  
DIMAGNO EP, 1982, GASTROENTEROLOGY, V83, P824
[9]  
ELDT S, 1994, PATHOL RES PRACT, V190, P1077
[10]   DIAGNOSIS OF PRIMARY GASTRIC LYMPHOMA [J].
FISCHBACH, W ;
BOHM, S .
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 1993, 118 (24) :909-912