Fondaparinux is a safe alternative in case of heparin intolerance during pregnancy

被引：72

作者：

Mazzolai, Lucia ^{[1
]}

Hohlfeld, Patrick

Spertini, Francois

Hayoz, Daniel

Schapira, Marc

Duchosal, Michel A.

机构：

[1] Univ Lausanne Hosp, Serv Vasc Med, Lausanne, Switzerland

[2] Univ Lausanne Hosp, Serv Obstet Immunol & Allergy, Lausanne, Switzerland

[3] Univ Lausanne Hosp, Serv Hematol, Lausanne, Switzerland

来源：

BLOOD | 2006年 / 108卷 / 05期

关键词：

D O I：

10.1182/blood-2006-03-009548

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heparin is the drug of choice for the treatment or the prevention of thromboembolic disease during pregnancy. However, treatment options are limited when heparin cannot be used because of hypersensitivity skin reactions. Despite the recent availability of new anticoagulant agents, data relating to their use during pregnancy are lacking. This report describes the successful management with fondaparinux, during 150 days, of a pregnant patient with protein S deficiency and prior deep vein thrombosis (DVT) who developed heparin and danaparoid hypersensitivity.

引用

页码：1569 / 1570

页数：2

共 16 条

[1] Minor transplacental passage of fondaparinux in vivo [J].

Dempfle, CEH .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (18) :1914-1915

[2] Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation [J].

Girardi, G ;

Redecha, P ;

Salmon, JE .

NATURE MEDICINE, 2004, 10 (11) :1222-1226

[3] Treatment of a woman with lupus pernio, thrombosis and cutaneous intolerance to heparins using lepirudin during pregnancy [J].

Harenberg, J ;

Jörg, I ;

Bayerl, C ;

Fiehn, C .

LUPUS, 2005, 14 (05) :411-412

[4] Intolerance of fondaparinux in a patient allergic to heparins [J].

Hirsch, K ;

Ludwig, RJ ;

Lindhoff-Last, E ;

Kaufmann, R ;

Boehncke, WH .

CONTACT DERMATITIS, 2004, 50 (06) :383-384

[5] Delayed-type hypersensitivity to the ultra-low-molecular-weight heparin fondaparinux [J].

Hohenstein, E ;

Tsakiris, D ;

Bircher, AJ .

CONTACT DERMATITIS, 2004, 51 (03) :149-151

[6] Management of heparin-associated thrombocytopenia in pregnancy with subcutaneous r-hirudin [J].

Huhle, G ;

Geberth, M ;

Hoffmann, U ;

Heene, DL ;

Harenberg, J .

GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 2000, 49 (01) :67-69

[7] Delayed-type hypersensitivity skin reactions due to heparins and heparinoids. Tolerance of recombinant hirudins and of the new synthetic anticoagulant fondaparinux [J].

Koch, P .

CONTACT DERMATITIS, 2003, 49 (06) :276-280

[8] Short- and long-acting synthetic pentasaccharides [J].

Koopman, MMW ;

Büller, HR .

JOURNAL OF INTERNAL MEDICINE, 2003, 254 (04) :335-342

[9] Successful treatment of heparin induced thrombocytopenia (HIT) with fondaparinux [J].

Kuo, KHM ;

Kovacs, MJ .

THROMBOSIS AND HAEMOSTASIS, 2005, 93 (05) :999-1000

[10] Treatment of 51 pregnancies with danaparoid because of heparin intolerance [J].

Lindhoff-Last, E ;

Kreutzenbeck, HJ ;

Magnani, HN .

THROMBOSIS AND HAEMOSTASIS, 2005, 93 (01) :63-69

← 1 2 →