IL-15/IL-15 receptor biology: A guided tour through an expanding universe

被引：363

作者：

Budagian, Vadirn

Bulanova, Elena

Paus, Ralf

Bulfone-Paus, Silvia ^{[1
]}

机构：

[1] Res Ctr Borstel, Dept Immunol & Cell Biol, D-23845 Borstel, Germany

[2] Univ Lubeck, Univ Hosp Schleswig Holstein, Dept Dermatol, D-23538 Lubeck, Germany

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2006年 / 17卷 / 04期

关键词：

IL-15; IL-15 receptor alpha; apoptosis; signal transduction; trans-presentation;

D O I：

10.1016/j.cytogfr.2006.05.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The cytokine interleukin-15 (IL-15) has a key role in promoting survival, proliferation and activation of natural killer (NK) and CD8+ T cells. Despite its functional similarities to IL-2, IL-15 affects a wider range of target cell populations and utilizes different mechanisms of signaling. Here, we review recent advances in the IL-15-mediated signaling, and in the functional properties on cells besides T lymphocytes and NK cells. These are discussed in the context of their potential clinical and therapeutic relevance. (c) 2006 Elsevier Ltd. All rights reserved.

引用

收藏

页码：259 / 280

页数：22

相关论文

共 218 条

[1]

Interleukin-6 and interleukin-15 are selectively regulated by lipopolysaccharide and interferon-γ in primary pig adipocytes [J].

Ajuwon, KM ;

Jacobi, SK ;

Kuske, JL ;

Spurlock, ME .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2004, 286 (03) :R547-R553

[2]

Effects of interleukin-15 (IL-15) on adipose tissue mass in rodent obesity models:: evidence for direct IL-15 action on adipose tissue [J].

Alvarez, B ;

Carbó, N ;

López-Soriano, J ;

Drivdahl, RH ;

Busquets, S ;

López-Soriano, FJ ;

Argilés, JM ;

Quinn, LS .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2002, 1570 (01) :33-37

[3]

Anti-interleukin-15 prevents arthritis in Borrelia-vaccinated and -infected mice [J].

Amlong, CA ;

Nardelli, DT ;

Peterson, SH ;

Warner, TF ;

Callister, SM ;

Schell, RF .

CLINICAL AND VACCINE IMMUNOLOGY, 2006, 13 (02) :289-296

[4]

CHROMOSOMAL ASSIGNMENT AND GENOMIC STRUCTURE OF IL15 [J].

ANDERSON, DM ;

JOHNSON, L ;

GLACCUM, MB ;

COPELAND, NG ;

GILBERT, DJ ;

JENKINS, NA ;

VALENTINE, V ;

KIRSTEIN, MN ;

SHAPIRO, DN ;

MORRIS, SW ;

GRABSTEIN, K ;

COSMAN, D .

GENOMICS, 1995, 25 (03) :701-706

[5]

ANDERSON DM, 1995, J BIOL CHEM, V270, P29862

[6]

Interleukin-15 promotes angiogenesis in vivo [J].

Angiolillo, AL ;

Kanegane, H ;

Sgadari, C ;

Reaman, GH ;

Tosato, G .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 233 (01) :231-237

[7]

CD4+CD25+ T regulatory cells, immunotherapy of cancer, and interleukin-2 [J].

Antony, PA ;

Restifo, NP .

JOURNAL OF IMMUNOTHERAPY, 2005, 28 (02) :120-128

[8]

Araki A, 2004, INT J MOL MED, V14, P571

[9]

Increased bioactive TNF in human systemic lupus erythematosus:: associations with cell death [J].

Aringer, M ;

Feierl, E ;

Steiner, G ;

Stummvoll, GH ;

Höfler, E ;

Steiner, CW ;

Radda, I ;

Smolen, JS ;

Graninger, WB .

LUPUS, 2002, 11 (02) :102-108

[10]

Serum interleukin-15 is elevated in systemic lupus erythematosus [J].

Aringer, M ;

Stummvoll, GH ;

Steiner, G ;

Köller, M ;

Steiner, CW ;

Höfler, E ;

Hiesberger, H ;

Smolen, JS ;

Graninger, WB .

RHEUMATOLOGY, 2001, 40 (08) :876-881

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