Molecules, Materials, Medicines (M3): Linking Molecules to Medicines through Pharmaceutical Material Science

被引:13
作者
Almarsson, Oern [1 ]
Vadas, Elizabeth B. [2 ]
机构
[1] Moderna Therapeut Inc, Cambridge, MA 02139 USA
[2] InSciTech Inc, Dorval, PQ, Canada
关键词
D O I
10.1021/acs.cgd.5b01417
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:5645 / 5647
页数:3
相关论文
共 12 条
[1]   Crystal engineering of the composition of pharmaceutical phases.: Do pharmaceutical co-crystals represent a new path to improved medicines? [J].
Almarsson, Ö ;
Zaworotko, MJ .
CHEMICAL COMMUNICATIONS, 2004, (17) :1889-1896
[2]   The co-crystal approach to improve the exposure of a water-insoluble compound: AMG 517 sorbic acid co-crystal characterization and pharmacokinetics [J].
Bak, Annette ;
Gore, Anu ;
Yanez, Evelyn ;
Stanton, Mary ;
Tufekcic, Sunita ;
Syed, Rashid ;
Akrami, Anna ;
Rose, Mark ;
Surapaneni, Sekhar ;
Bostick, Tracy ;
King, Anthony ;
Neervannan, Sesha ;
Ostovic, Drazen ;
Koparkar, Arun .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2008, 97 (09) :3942-3956
[3]   Development of an Early-Phase Bulk Enabling Route to Sodium-Dependent Glucose Cotransporter 2 Inhibitor Ertugliflozin [J].
Bernhardson, David ;
Brandt, Thomas A. ;
Hulford, Catherine A. ;
Lehner, Richard S. ;
Preston, Brian R. ;
Price, Kristin ;
Sagal, John F. ;
St Pierre, Michael J. ;
Thompson, Peter H. ;
Thuma, Benjamin .
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2014, 18 (01) :57-65
[4]   Assessment of the physical stability of lyophilized MK-0591 by differential scanning calorimetry [J].
Clas, SD ;
Cotton, M ;
Moran, E ;
Spagnoli, S ;
Zografi, G ;
Vadas, EB .
THERMOCHIMICA ACTA, 1996, 288 (1-2) :83-96
[5]   The potency-insolubility conundrum in pharmaceuticals: Mechanism and solution for hepatitis C protease inhibitors [J].
Connelly, Patrick R. ;
Snyder, Phillip W. ;
Zhang, Yuegang ;
McClain, Brian ;
Quinn, Brian P. ;
Johnston, Steve ;
Medek, Ales ;
Tanoury, Jerry ;
Griffith, James ;
Walters, W. Patrick ;
Dokou, Eleni ;
Knezic, Dragutin ;
Bransford, Philip .
BIOPHYSICAL CHEMISTRY, 2015, 196 :100-108
[6]   Downstream processing of polymer-based amorphous solid dispersions to generate tablet formulations [J].
Demuth, B. ;
Nagy, Z. K. ;
Balogh, A. ;
Vigh, T. ;
Marosi, G. ;
Verreck, G. ;
Van Assche, I. ;
Brewster, M. E. .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2015, 486 (1-2) :268-286
[7]   Cyclodextrins as functional excipients: Methods to enhance complexation efficiency [J].
Loftsson, Thorsteinn ;
Brewster, Marcus E. .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2012, 101 (09) :3019-3032
[8]   On the importance of synthetic organic chemistry in drug discovery: reflections on the discovery of antidiabetic agent ertugliflozin [J].
Mascitti, Vincent ;
Thuma, Benjamin A. ;
Smith, Aaron C. ;
Robinson, Ralph P. ;
Brandt, Thomas ;
Kalgutkar, Amit S. ;
Maurer, Tristan S. ;
Samas, Brian ;
Sharma, Raman .
MEDCHEMCOMM, 2013, 4 (01) :101-111
[9]   Glass-Liquid Phase Separation in Highly Supersaturated Aqueous Solutions of Telaprevir [J].
Mosquera-Giraldo, Laura I. ;
Taylor, Lynne S. .
MOLECULAR PHARMACEUTICS, 2015, 12 (02) :496-503
[10]   Assessing the performance of amorphous solid dispersions [J].
Newman, Ann ;
Knipp, Gregory ;
Zografi, George .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2012, 101 (04) :1355-1377