Atorvastatin does not alter the anticoagulant activity of warfarin

被引：33

作者：

Stern, R

Abel, R

Gibson, GL

Besserer, J

机构：

[1] WARNER LAMBERT PARKE DAVIS,PARKE DAVIS PHARMACEUT RES,DEPT BIOMETR,ANN ARBOR,MI

[2] WARNER LAMBERT PARKE DAVIS,PARKE DAVIS PHARMACEUT RES,DEPT CLIN COMMUN,ANN ARBOR,MI

[3] NEUROL ASSOCIATES PA,LITTLE ROCK,AR

来源：

JOURNAL OF CLINICAL PHARMACOLOGY | 1997年 / 37卷 / 11期

关键词：

D O I：

10.1002/j.1552-4604.1997.tb04288.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Twelve patients chronically maintained on warfarin were administered 80 mg atorvastatin for 2 weeks. Mean prothrombin times decreased slightly, but only for the first few days of the two-week treatment period. Thus atorvastatin had no consistent effect on the anticoagulant activity of warfarin and adjustments in warfarin dosing should not be necessary.

引用

页码：1062 / 1064

页数：3

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