Identifying the Association Between Alzheimer's Disease and Parkinson's Disease Using Genome-Wide Association Studies and Protein-Protein Interaction Network

被引：37

作者：

Liu, Guiyou ^{[1
,2
]}

Bao, Xinjie ^{[3
,4
]}

Jiang, Yongshuai ^{[5
]}

Liao, Mingzhi ^{[6
]}

Jiang, Qinghua ^{[7
]}

Feng, Rennan ^{[8
]}

Zhang, Liangcai ^{[9
]}

Ma, Guoda ^{[1
]}

Chen, Zugen ^{[10
]}

Wang, Guangyu ^{[11
]}

Wang, Renzhi ^{[3
,4
]}

Zhao, Bin ^{[1
]}

Li, Keshen ^{[1
]}

机构：

[1] Guangdong Med Coll, Inst Neurol, Zhanjiang 524001, Peoples R China

[2] Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Genome Anal Lab, Tianjin Airport Econ Area, Tianjin 300308, Peoples R China

[3] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Neurosurg, Beijing 100730, Peoples R China

[4] Peking Union Med Coll, Beijing 100730, Peoples R China

[5] Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin, Peoples R China

[6] Northwest A&F Univ, Coll Life Sci, Yangling, Shaanxi, Peoples R China

[7] Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150006, Peoples R China

[8] Harbin Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Harbin, Peoples R China

[9] Rice Univ, Dept Stat, Houston, TX 77251 USA

[10] Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA USA

[11] First Hosp Harbin, Dept Oncol, Harbin, Peoples R China

来源：

MOLECULAR NEUROBIOLOGY | 2015年 / 52卷 / 03期

关键词：

Alzheimer's disease; Parkinson's disease; Genome-wide association studies; Gene expression; Protein-protein interaction network; RISK LOCI; METAANALYSIS; GENES; EXPRESSION; SNCA; MAPT;

D O I：

10.1007/s12035-014-8946-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Alzheimer's disease (AD) and Parkinson's disease (PD) are the first and second most common neurodegenerative diseases in the elderly. Shared clinical and pathological features have been reported. Recent large-scale genome-wide association studies (GWAS) have been conducted and reported a number of AD and PD variants. Until now, the underlying genetic mechanisms for all these newly identified PD variants as well as the association between AD and PD are still unclear exactly. We think that PD variants may contribute to AD and PD by influence on brain gene expression. Here, we conducted a systems analysis using (1) AD and PD variants (P < 5.00E-08) identified by the published GWAS; (2) four brain expression GWAS datasets using expression quantitative trait loci from the cerebellum and temporal cortex; (3) large-scale AD GWAS from the Alzheimer Disease Genetics Consortium (ADGC); (4) a protein-protein interaction network. Our results indicated that PD variants around the 17q21 were associated with gene expression and suggestive AD risk. We also identified significant interaction among AD and PD susceptibility genes. We believe that our findings may explain the underlying genetic mechanisms for newly identified PD variants in PD and AD, as well as the association between AD and PD, which may be very useful for future genetic studies for both diseases.

引用

页码：1629 / 1636

页数：8

共 26 条

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