A second CYP26P450 in humans and zebrafish: CYP26B1

被引：39

作者：

Nelson, DR ^{[1
]}

机构：

[1] Univ Tennessee, Dept Biochem, Memphis, TN 38163 USA

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1999年 / 371卷 / 02期

关键词：

cytochrome P450; retinoic acid; CYP26; human; zebrafish;

D O I：

10.1006/abbi.1999.1438

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new P450 gene has been found in humans. It has 44% sequence identity to CYP26A1 from human and mouse, which places it in a new subfamily, CYP26B. There is only one human EST from a retinal library (AA012833) that matches the coding region. Mo homologous ESTs are found in mouse. A zebrafish EST AI721901 shows 68% identity to the human protein. This zebrafish EST is only 41% identical to the zebrafish CYP26A1 protein sequence, so it represents the homolog of the human CYP26B1 sequence. It is not known if this gene product will act on all-trans-retinoic acid like the CYP26A1 protein or if it might hydroxylate the 9-cis- or 13-cis-retinoic acid isoforms not recognized by CYP26A1. The importance of the CYP26A1 P450 in mouse and zebrafish development flags the CYP26B1 gene as a potential developmental gene. (C) 1999 Academic Press.

引用

收藏

页码：345 / 347

页数：3

相关论文

共 13 条

[1] Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor γ and retinoid X receptor α [J].

Abu-Abed, SS ;

Beckett, BR ;

Chiba, H ;

Chithalen, JV ;

Jones, G ;

Metzger, D ;

Chambon, P ;

Petkovich, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (04) :2409-2415

[2] Expression of retinoic acid 4-hydroxylase (CYP26) during mouse and Xenopus laevis embryogenesis [J].

de Roos, K ;

Sonneveld, E ;

Compaan, P ;

ten Berge, D ;

Durston, AJ ;

van der Saag, PT .

MECHANISMS OF DEVELOPMENT, 1999, 82 (1-2) :205-211

[3] Regionalized metabolic activity establishes boundaries of retinoic acid signalling [J].

Hollemann, T ;

Chen, YL ;

Grunz, H ;

Pieler, T .

EMBO JOURNAL, 1998, 17 (24) :7361-7372

[4] A molecular basis for retinoic acid-induced axial truncation [J].

Iulianella, A ;

Beckett, B ;

Petkovich, M ;

Lohnes, D .

DEVELOPMENTAL BIOLOGY, 1999, 205 (01) :33-48

[5] Retinoic acid receptors regulate expression of retinoic acid 4-hydroxylase that specifically inactivates all-trans retinoic acid in human keratinocyte HaCaT cells [J].

Marikar, Y ;

Wang, ZQ ;

Duell, EA ;

Petkovich, M ;

Voorhees, JJ ;

Fisher, GJ .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1998, 111 (03) :434-439

[6] Dorsal and ventral retinal territories defined by retinoic acid synthesis, break-down and nuclear receptor expression [J].

McCaffery, P ;

Wagner, E ;

O'Neil, J ;

Petkovich, M ;

Dräger, UC .

MECHANISMS OF DEVELOPMENT, 1999, 82 (1-2) :119-130

[7] Cytochrome P450 and the individuality of species [J].

Nelson, DR .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1999, 369 (01) :1-10

[8] CYP26, a novel mammalian cytochrome P450, is induced by retinoic acid and defines a new family [J].

Ray, WJ ;

Bain, G ;

Yao, M ;

Gottlieb, DI .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (30) :18702-18708

[9]

Sonneveld E, 1998, CELL GROWTH DIFFER, V9, P629

[10] Expression of cytochrome P450RAI (CYP26) in human fetal hepatic and cephalic tissues [J].

Trofimova-Griffin, ME ;

Juchau, MR .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 252 (02) :487-491