DNA damage and repair in atherosclerosis

被引：114

作者：

Mahmoudi, Melli ^{[1
]}

Mercer, John ^{[1
]}

Bennett, Martin ^{[1
]}

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Div Cardiovasc Med, Cambridge CB2 2QQ, England

来源：

CARDIOVASCULAR RESEARCH | 2006年 / 71卷 / 02期

关键词：

atherosclerosis; oxygen radicals;

D O I：

10.1016/j.cardiores.2006.03.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is increasing evidence that human atherosclerosis is associated with damage to the DNA of both circulating cells, and cells of the vessel wall. Reactive oxygen species are the most likely agents inducing DNA damage in atherosclerosis. DNA damage produces a variety of responses, including cell senescence, apoptosis and DNA repair. This review summarises the evidence for DNA damage in atherosclerosis, the cellular responses to damage and the mechanisms of signalling DNA damage. (c) 2006 European Society of Cardiology. Published by Elsevier B.V All rights reserved.

引用

页码：259 / 268

页数：10

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