Attentional modulation of emotional stimulus processing: An fMRl study using emotional expectancy

被引:78
作者
Bermpohl, Felix
Pascual-Leone, Alvaro
Amedi, Amir
Merabet, Lotfi B.
Fregni, Felipe
Gaab, Nadine
Alsop, David
Schlaug, Gottfried
Northoff, Georg
机构
[1] Univ Med Berlin, Charite, Dept Psychiat & Psychotherapy, D-10117 Berlin, Germany
[2] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Ctr NonInvas Brain Stimulat, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol,Lab Funct Neuroimaging, Boston, MA 02115 USA
[4] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA
[5] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Radiol,Ctr Adv Imaging, Boston, MA 02115 USA
[6] Univ Magdeburg, Dept Psychiat & Psychotherapy, D-39106 Magdeburg, Germany
关键词
emotion; attention; functional magnetic resonance imaging; medial prefrontal cortex; amygdala;
D O I
10.1002/hbm.20209
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We used emotional expectancy to study attentional modulation in the processing of emotional stimuli. During functional magnetic resonance imaging (fMRI), volunteers saw emotional and neutral expectancy cues signaling the subsequent presentation of corresponding emotional or neutral pictorial stimuli. As a control, emotional and neutral pictures were presented without preceding expectancy cue, resulting in a 2 X 2 factorial design with the factors "expectancy" and "emotion." Statistical analysis revealed a significant positive interaction effect between these factors in the medial prefrontal cortex (MPFC, Brodmann area [BA] 9/10), amygdala, and dorsal midbrain. In all these regions, expectancy augmented the neural response to emotional but not to neutral pictures. Time course analysis of raw data suggests that this augmented activation was not preceded by baseline increases in MPFC and amygdala during the period of emotional expectancy. In a post-scanning session, the paradigm was presented for a second time to allow emotional intensity rating. Again, a significant interaction between expectancy and emotion was observed, with intensity ratings specifically enhanced in emotional photographs preceded by expectancy. There was a positive correlation between intensity ratings and blood oxygenation level-dependent (BOLD) signals in the left amygdala. We conclude that specific components of the emotion network show enhanced activation in response to emotional stimuli when these are preceded by expectancy. This enhancement effect is not present in neutral pictures and might parallel accentuated subjective feeling states.
引用
收藏
页码:662 / 677
页数:16
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