Interim analysis of a prospective, randomized trial of vacuum-assisted closure versus the healthpoint system in the management of pressure ulcers

被引：140

作者：

Ford, CN ^{[1
]}

Reinhard, ER ^{[1
]}

Yeh, D ^{[1
]}

Syrek, D ^{[1
]}

de las Morenas, A ^{[1
]}

Bergman, SB ^{[1
]}

Williams, S ^{[1
]}

Hamori, CA ^{[1
]}

机构：

[1] Boston Univ, Sch Med, Boston, MA 02215 USA

来源：

ANNALS OF PLASTIC SURGERY | 2002年 / 49卷 / 01期

关键词：

D O I：

10.1097/00000637-200207000-00009

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Twenty-eight patients with 41 full-thickness decubitus ulcers were randomized to compare the Vacuum-Assisted Closure device (VAC) with the Healthpoint System (HP) of wound gel products in promoting ulcer healing. A total of 22 patients with 35 full-thickness ulcers completed the 6-week trial of treatment, during which time 2 patients (10%) in the VAC group (N = 20) and 2 patients (13%) in the HIP group (N = 15) healed completely. The mean percent reduction in ulcer volume was 42.1% with HIP and 51.8% with VAC (P = 0.46). The mean number of PMNs and lymphocytes per high-power field decreased in the VAC group and increased in the HIP group (p = 0.13, p = 0.41 respectively). The mean number of capillaries per high-power field was greater in the VAC group (p = 0.75). There were 15 cases of biopsy-proven osteomyelitis underlying the ulcers; three (37.5%) improved with VAC and none improved with HP (p = 0.25). VAC promotes an increased rate of wound healing and favorable histological changes in soft tissue and bone compared with HP.

引用

页码：55 / 61

页数：7

共 13 条

[1] Vacuum-assisted closure: A new method for wound control and treatment: Clinical experience [J].