Toll-like receptors and innate immunity

被引：347

作者：

Uematsu, Satoshi

Akira, Shizuo

机构：

[1] ERATO, Japan Sci & Technol Corp, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Dept Host Def, Microbial Dis Res Inst, Suita, Osaka 5650851, Japan

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 2006年 / 84卷 / 09期

关键词：

TLR; NLR; RIG-I;

D O I：

10.1007/s00109-006-0084-y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The innate immune system is an evolutionally conserved host defense mechanism against pathogens. Innate immune responses are initiated by pattern recognition receptors (PRRs), which recognize specific structures of microorganisms. Among them, Toll-like receptors (TLRs) are capable of sensing organisms ranging from bacteria to fungi, protozoa, and viruses, and play a major role in innate immunity. However, TLRs recognize pathogens either on the cell surface or in the lysosome/endosome compartment. Recently, cytoplasmic PRRs have been identified to detect pathogens that have invaded cytosols. In this review, we focus on the functions of PRRs in innate immunity and their downstream signaling cascades.

引用

收藏

页码：712 / 725

页数：14

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