Hypoglycemia, Chronic Kidney Disease, and Diabetes Mellitus

被引:74
作者
Alsahli, Mazen [1 ]
Gerich, John E. [2 ]
机构
[1] Univ Toronto, Fac Med, Dept Med, Toronto, ON, Canada
[2] Univ Rochester, Sch Med & Dent, Dept Med, Rochester, NY 14642 USA
关键词
GLOMERULAR-FILTRATION-RATE; GLUCOSE COUNTERREGULATION; NOCTURNAL HYPOGLYCEMIA; RENAL-INSUFFICIENCY; INSULIN SENSITIVITY; RISK-FACTORS; TYPE-1; FREQUENCY; ASSOCIATION; PHARMACOKINETICS;
D O I
10.1016/j.mayocp.2014.07.013
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Hypoglycemia is a major problem associated with substantial morbidity and mortality in patients with diabetes and is often a major barrier to achieving optimal glycemic control. Chronic kidney disease not only is an independent risk factor for hypoglycemia but also augments the risk of hypoglycemia that is already present in people with diabetes. This article summarizes our current knowledge of the epidemiology, pathogenesis, and morbidity of hypoglycemia in patients with diabetes and chronic kidney disease and reviews therapeutic considerations in this situation. PubMed and MEDLINE were searched for literature published in English from January 1989 to May 2014 for diabetes mellitus, hypoglycemia, chronic kidney disease, and chronic renal insufficiency. (C) 2014 Mayo Foundation for Medical Education and Research
引用
收藏
页码:1564 / 1571
页数:8
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